[1]刘慰,司传领*,杜海顺,等.纳米纤维素基水凝胶的制备及其在生物医学领域的应用进展[J].林业工程学报,2019,4(05):11-19.[doi:10.13360/j.issn.2096-1359.2019.05.002]
　LIU Wei,SI Chuanling*,DU Haishun,et al.Advance in preparation of nanocellulose-based hydrogels and their biomedical applications[J].Journal of Forestry Engineering,2019,4(05):11-19.[doi:10.13360/j.issn.2096-1359.2019.05.002]
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纳米纤维素基水凝胶的制备及其在生物医学领域的应用进展()
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《林业工程学报》[ISSN:1001-8081/CN:32-1160/S]

卷:
4
期数:
2019年05期
页码:
11-19
栏目:
专论综述
出版日期:
2019-09-16

文章信息/Info

Title:
Advance in preparation of nanocellulose-based hydrogels and their biomedical applications
文章编号:
2096-1359(2019)05-0011-09
作者:
刘慰1; 司传领1*; 杜海顺2; 张苗苗2; ZHANG Xinyu2; 解洪祥1
1.天津科技大学,天津市制浆造纸重点实验室,天津 300457; 2.Department of Chemical Engineering, Auburn University, Auburn 36849, USA
Author(s):
LIU Wei1;  SI Chuanling1*;  DU Haishun2;  ZHANG Miaomiao2;  ZHANG Xinyu2;  XIE Hongxiang1
1.Tianjin Key Laboratory of Pulp and Paper, Tianjin University of Science & Technology, Tianjin 300457, China; 2.Department of Chemical Engineering, Auburn University, Auburn 36849, USA
关键词:
纤维素纳米晶体;  纤维素纳米纤维;  水凝胶;  生物医学应用
Keywords:
cellulose nanofibrils;  cellulose nanocrystals;  hydrogels;  biomedical applications
分类号:
TQ352
DOI:
10.13360/j.issn.2096-1359.2019.05.002
文献标志码:
A
摘要:
纤维素纳米晶体(cellulose nanocrystals, CNCs)和纤维素纳米纤维(cellulose nanofibrils, CNFs)具有独特的理化性质,例如,比表面积高(>100 m2/g)、机械性能优越(弹性模量130～150 GPa)、密度低(低至1.6 g/cm3)、膨胀系数小(低至0.1×10-6/K)、生物相容性好、表面多羟基结构容易进一步修饰等,且原料易得、可再生和生物降解,是理想的先进功能材料构建砌块,已被证明是具有良好应用前景的生物基纳米材料。近年来,纳米纤维素基水凝胶引起了大量的关注,并且其在生物医学领域的应用得到了广泛研究。笔者主要综述了CNCs和CNFs基水凝胶的制备及其在生物医学应用的研究进展。首先介绍了制备CNCs基水凝胶的物理交联法和化学交联法,以及CNFs与金属离子交联、CNFs与聚合物交联两种制备CNFs基水凝胶的方法; 其次重点介绍了CNCs和CNFs基水凝胶在药物递送、创伤敷料和组织工程支架中的应用; 最后总结了CNCs和CNFs基水凝胶在生物医学领域的应用前景和面临挑战,并指明了CNCs和CNFs基水凝胶在生物医学领域研究的发展方向。
Abstract:
Nanocellulose with nano size at least in one dimension is derived from cellulosic source(e.g.lignocellulosic biomass)through physical, chemical or combined methods, and recently it has drawn extensive attentions from both the academic and industrial areas due to its unique structure and exceptional properties, such as high specific surface areas(>100 m2/g), superior mechanical properties(modulus of elasticity 130-150 GPa), low density(low to 1.6 g/cm3), low expansion coefficient(around 0.1×10-6/K), significant optical properties, good biocompatibility, and abundant hydroxyl groups, which are beneficial to further surface functionalization.Moreover, the raw cellulose materials used to produce nanocellulose are renewable, biodegradable and with a huge amount of annual production(75-100 billion tons).Thus, as the ideal advanced building block for constructing various sustainable and functional materials, nanocellulose has been proved to be a promising bio-based nanomaterial.Generally, nanocellulose can be divided into two main categories: cellulose nanocrystal(CNCs)and cellulose nanofibril(CNFs),based on the differences in preparation and fabrication methods and properties.In general, CNC are rigid rod-like particles of 10-50 nm in width and several hundred nanometers in length and with high crystallinity.On the other hand, CNF with semi-crystalline structure are flexible fiber-like with a diameter less than 100 nm and a length of 500 nm to several microns.In recent years, CNCs and CNFs based hydrogels have attracted a great deal of attentions, and their applications in the biomedical field have been extensively studied.This paper mainly reviewed the preparation of CNCs- and CNFs-based hydrogels and their research progress in biomedical applications.Based on the differences in structures and properties, the preparation strategies of CNCs-based hydrogels(e.g.physical and chemical crosslinking)and CNFs-based hydrogels(e.g.CNFs-metal ion crosslinking, CNFs-polymer crosslinking)were introduced separately.In the biomedical applications section, the applications of CNCs- and CNFs-based hydrogels in drug delivery, wound dressing and tissue engineering scaffolds were highlighted.Additionally, the application prospects and challenges of CNCs- and CNFs-based hydrogels in biomedical fields were also summarized, and the future development direction and potential application aspects of CNCs- and CNFs-based hydrogels in the biomedical field was pointed out.

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备注/Memo

备注/Memo:
收稿日期:2019-03-02 修回日期:2019-04-18
基金项目:第63批中国博士后科学基金面上资助(2018M631749)。
作者简介:刘慰,女,博士,研究方向为农林生物质高值转化利用。通信作者:司传领,男,教授。 E-mail: sichli@tust.edu.cn
更新日期/Last Update: 2019-09-10